Protein Interactions at the Tight Junction
نویسندگان
چکیده
منابع مشابه
Protein Interactions at the Tight Junction
Defining how the molecular constituents of the tight junction interact is a prerequisite to understanding tight junction physiology. We utilized in vitro binding assays with purified recombinant proteins and immunoprecipitation analyses to define interactions between ZO-1, ZO-2, ZO-3, occludin, and the actin cytoskeleton. Actin cosedimentation studies showed that ZO-2, ZO-3, and occludin all in...
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Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that is projected to have two extracellular loops. We have used peptides emulating central regions of human occludin's first and second loops, termed O-A:101-121 and O-B:210-228, respectively, to examine potential molecular interactions between these two regions of occludin and other T...
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Claudins form the paracellular tight junction seal in epithelial tissues. Although there is still limited information on how these proteins are organized at the junction, a number of recent studies have provided useful insights both into claudin-claudin interactions and into interactions between claudins and other proteins. The focus of this review is to summarize recent information about claud...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.49.35179